Once Human Combat Strategies and Guide - 2025

Once Human offers you a world full of foes to challenge and battle against. Dedication is not enough to be victorious in every challenging battle; you need the best tips to master the Once Human combat. All of them are listed in this guide. After going through it, you can play Once Human on PC with LDPlayer, earning victories in every combat. 

 

Equip the Best Weapons

 

Choosing and equipping the best weapons is about finding the right tools to match your playstyle, and by doing so, you can get better at the Once Human combat. Weapons determine how effectively you can take down enemies and the best weapons offer a balance of damage, usability, and versatility, ensuring you're prepared for any situation. 

A high-damage sniper is recommended here for long-range engagements, while a rapid-fire SMG could save you in close-quarters chaos. Picking the right weapon and keeping it upgraded means surviving longer and thriving in a world where resources are scarce, and danger is constant.

 

How to Get the Best Weapons 

 

Getting top-tier weapons requires effort, strategy, and sometimes a bit of luck. The best arsenal can be obtained in this way.

• Weapon and Ammunition Crafting - Start with the basics, crafting. Unlock Gear Workbenches and Ammunition paths in the Crafting Tab under Memetics. Early weapons like pistols or shotguns can be made with common materials, but as you progress, you'll craft stronger options like LMGs or Heavy Artillery. 
• Weapon Blueprints - Explore dangerous zones, loot crates, and defeat tough enemies to gather fragments. Once you've got a blueprint, craft the weapon with the right materials and watch your combat potential increase.
• Wish Machine - The Wish Machine offers a gacha-style chance to get blueprints for elite weapons. Save up currency from missions and events to spin for the best rewards.

 

Upgrade Your Combat Loadout 

 

Getting a great weapon is only the first step; upgrading it keeps it relevant as enemies get tougher to get better at the Once Human combat. You can increase the stats of the weapons in your loadout and increase their power by upgrading them as follows.  

• Weapon Enhancement - Use Blueprint Fragments to boost a weapon's Star Rating. Each upgrade improves base stats like damage and accuracy. Prioritize enhancing the weapons you rely on most to maximize your investment.
• Weapon Customization - Craft accessories like scopes, grips, or extended magazines to power up your weapon. A sniper rifle with a high-powered scope becomes a precision tool, while an SMG with better stability lets you spray bullets without losing control. 
• Using Mods - Mods add another layer of power. Each mod has a core effect like bonus critical damage plus random attributes based on its tier. 

 

Get Yourself the Strongest Combat Deviants 

 

In Once Human combat victories, Combat Deviants are essential, offering damage, buffs, or healing. Picking the best and boosting their power is your ticket to survival. Some of the strongest combat deviants that you should capture in the game are as follows. 

• Lonewolf's Whisper - This deviant summons wolves for great damage, and this is ideal for aggressive players.  
• Festering Gel - It has the ability to heal you over time, and it is perfect for boss fights.  
• Butterfly's Emissary - This is an early-game melee striker that scales well.  
• Zeno-Purifier - This one is good at teleporting samurai for precision kills.  
• Dr. Teddy - This unit deals and revives, which is great for PvP. 

Make sure you pick the strongest combat deviants based on your style. If you follow an offensive style, you should try Lone Wolf, and if you want to focus more on defense, Festering Gel would be a great option. But if you want a hybrid deviant who excels in every role, Butterfly is your best pick. 

Another thing to pay attention to when using combat deviants is to upgrade their powers, making them stronger against any foe. You can increase your deviants' power by doing the following. 

• Sync to Cradle - Place them in an Isolated Securement Unit, sync, and deploy them to combat. You can deploy one deviant at a time, so choose wisely.  
• Optimize Environment - Check preferences for each unit and fulfill them to enhance their moods and make them active and strong. Different preferences are needed for different deviants.  

 

Master the Combat Controls 

 

One of the main tips to follow to master the Once Human combat is to master the combat controls first. From the beginning, you encounter and engage in fights against enemies within this game and to reflect your skills in each combat; you should master it perfectly. 

To do so, you should be familiar with the controls given in the game. Hesitation over a missed key can cost you against a horde or a brutal boss. So, you should be familiar with and used to the controls for faster reactions, better combos, and staying alive when ammo's tight, and enemies swarm.

The best way to nail this is to use LDPlayer, as it has the Keyboard Mapping feature that lets you customize your keyboard shortcuts, making controls intuitive and lightning-quick. With its help, you can set keys that fit your style and practice against early mobs or raids. 

 

Understand the Weakness of Every Enemy 

 

Every enemy has a weak spot or vulnerability that, once exploited, turns tough fights into swift victories. Mastering combat means spotting these openings and hitting them hard. For example, take the Gnawer, a hulking mutant. You can easily damage it massively by aiming for its head, and your shots deal bonus damage, dropping it faster than body hits ever could. 

It's all about reading the room. If the enemies are slow, you can kite them with an SMG. Don't hesitate to blast fast enemies apart with a shotgun or let Lonewolf's Whisper's wolf pack tear through the crowd. For armored foes that shrug off regular rounds, craft elemental ammo like fire rounds at a Supplies Workbench to burn through their defenses in a satisfying blaze. 

 

Conclusion

 

Using the best tips and strategies you have learned, you can master combat easily. Once you master it, you will always be victorious in every challenge. As a Once Human beginner, these tips will help you understand the best ways to win challenges. Also, check out the Once Human codes to obtain resources and rare benefits to your game for free, which will boost your gameplay progression even more.